RadGridView supports the standard Windows Forms data binding model, so it will bind to a variety of data sources. In most circumstances its DataSource property will be bound to a BindingSource component which will manage the interaction with the data source. The BindingSource component can represent any Windows Forms data source and gives you great flexibility when choosing or modifying the location of your data.
If the DataSource is set to a dataset object with multiple tables, you can set the the DataMember property to the name of the table that the control should display. See Databinding RadGridView for an overview of binding to many popular data types.