RadTreeListView exposes several useful events, which can help you to control the mouse interaction and to get notified when mouse events occur. Moreover, by using the mouse you can perform some of the most common tasks:
Change the selection.
Sort by clicking on the column headers.
Resize and reorder columns.
Define\Remove simple filters.
Start\End cell editing.
As the RadTreeListView directly inherits the RadGridView it handles the mouse in the same way. To learn more read the respective topic in the RadGridView's documentation.